Our starting point is the primary sequence of the heavy and light chain variable regions of your candidate antibody. The consultancy applies a series of proven analytical and knowledge-based design strategies to produce the DNA sequences of a set of humanized antibody heavy and light chain variants.
Downstream, we work in partnership with your laboratory scientists to assist and guide them during the generation, expression and testing of the variants, designed by our team, and the selection of the final constructs to be taken into cell line development and manufacture.
We also provide expert advice on a variety of antibody engineering and expression issues to facilitate the development of your potential therapeutic antibody.
